Regulation of Lean Mass, Bone Mass, and Exercise Tolerance by the Central Melanocortin System

Signaling via the type 4-melanocortin receptor (MC4R) is an important determinant of body weight in mice and humans, where loss of function mutations lead to significant obesity. Humans with mutations in the MC4R experience an increase in lean mass. However, the simultaneous accrual of fat mass in s...

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Main Authors: Braun, Theodore P., Orwoll, Benjamin, Zhu, Xinxia, Levasseur, Peter R., Szumowski, Marek, Nguyen, My Linh T., Bouxsein, Mary L., Klein, Robert F., Marks, Daniel L.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407101/
https://ncbi.nlm.nih.gov/pubmed/22848742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042183
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