Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter

BACKGROUND: Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either of two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene in aldosterone producing adenomas. Th...

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Main Authors: Åkerström, Tobias, Crona, Joakim, Delgado Verdugo, Alberto, Starker, Lee F., Cupisti, Kenko, Willenberg, Holger S., Knoefel, Wolfram T., Saeger, Wolfgang, Feller, Alfred, Ip, Julian, Soon, Patsy, Anlauf, Martin, Alesina, Pier F., Schmid, Kurt W., Decaussin, Myriam, Levillain, Pierre, Wängberg, Bo, Peix, Jean-Louis, Robinson, Bruce, Zedenius, Jan, Bäckdahl, Martin, Caramuta, Stefano, Iwen, K. Alexander, Botling, Johan, Stålberg, Peter, Kraimps, Jean-Louis, Dralle, Henning, Hellman, Per, Sidhu, Stan, Westin, Gunnar, Lehnert, Hendrik, Walz, Martin K., Åkerström, Göran, Carling, Tobias, Choi, Murim, Lifton, Richard P., Björklund, Peyman
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407065/
https://ncbi.nlm.nih.gov/pubmed/22848660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041926
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