Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter

BACKGROUND: Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either of two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene in aldosterone producing adenomas. Th...

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Main Authors: Åkerström, Tobias, Crona, Joakim, Delgado Verdugo, Alberto, Starker, Lee F., Cupisti, Kenko, Willenberg, Holger S., Knoefel, Wolfram T., Saeger, Wolfgang, Feller, Alfred, Ip, Julian, Soon, Patsy, Anlauf, Martin, Alesina, Pier F., Schmid, Kurt W., Decaussin, Myriam, Levillain, Pierre, Wängberg, Bo, Peix, Jean-Louis, Robinson, Bruce, Zedenius, Jan, Bäckdahl, Martin, Caramuta, Stefano, Iwen, K. Alexander, Botling, Johan, Stålberg, Peter, Kraimps, Jean-Louis, Dralle, Henning, Hellman, Per, Sidhu, Stan, Westin, Gunnar, Lehnert, Hendrik, Walz, Martin K., Åkerström, Göran, Carling, Tobias, Choi, Murim, Lifton, Richard P., Björklund, Peyman
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407065/
https://ncbi.nlm.nih.gov/pubmed/22848660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041926
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