PDE4 Inhibition Suppresses IL-17–Associated Immunity in Dry Eye Disease

PURPOSE. To determine the effect of phosphodiesterase type-4 (PDE4) inhibition on IL-17–associated immunity in experimental dry eye disease (DED). METHODS. Murine DED was induced, after which a PDE4 inhibitor (cilomilast), dexamethasone, cyclosporine, or a relevant vehicle was administered topically...

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Hlavní autoři: Sadrai, Zahra, Stevenson, William, Okanobo, Andre, Chen, Yihe, Dohlamn, Thomas H., Hua, Jing, Amparo, Francisco, Chauhan, Sunil K., Dana, Reza
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406885/
https://ncbi.nlm.nih.gov/pubmed/22577075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-9110
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