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Inhibition of the MRP1-mediated transport of the menadione-glutathione conjugate (thiodione) in HeLa cells as studied by SECM

Oxidative stress induced in live HeLa cells by menadione (2-methyl-1,4-napthaquinone) was studied in real time by scanning electrochemical microscopy (SECM). The hydrophobic molecule menadione diffuses through a living cell membrane where it is toxic to the cell. However, in the cell it is conjugate...

詳細記述

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書誌詳細
主要な著者: Koley, Dipankar, Bard, Allen J.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406878/
https://ncbi.nlm.nih.gov/pubmed/22679290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201555109
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