Trypanosoma brucei 20 S Editosomes Have One RNA Substrate-binding Site and Execute RNA Unwinding Activity

Editing of mitochondrial pre-mRNAs in African trypanosomes generates full-length transcripts by the site-specific insertion and deletion of uridylate nucleotides. The reaction is catalyzed by a 0.8 MDa multienzyme complex, the editosome. Although the binding of substrate pre-edited mRNAs and cognate...

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Bibliografiske detaljer
Main Authors: Böhm, Cordula, Katari, Venkata Subbaraju, Brecht, Michael, Göringer, H. Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406711/
https://ncbi.nlm.nih.gov/pubmed/22661715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365916
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