Phosphorylation of Adaptor Protein Containing Pleckstrin Homology Domain, Phosphotyrosine Binding Domain, and Leucine Zipper Motif 1 (APPL1) at Ser(430) Mediates Endoplasmic Reticulum (ER) Stress-induced Insulin Resistance in Hepatocytes

APPL1 is an adaptor protein that plays a critical role in regulating adiponectin and insulin signaling. However, how APPL1 is regulated under normal and pathological conditions remains largely unknown. In this study, we show that APPL1 undergoes phosphorylation at Ser(430) and that this phosphorylat...

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Hlavní autoři: Liu, Meilian, Zhou, Lijun, Wei, Li, Villarreal, Ricardo, Yang, Xin, Hu, Derong, Riojas, Ramon A., Holmes, Bekke M., Langlais, Paul R., Lee, Hakjoo, Dong, Lily Q.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406692/
https://ncbi.nlm.nih.gov/pubmed/22685300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372292
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