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Conjugation of Glutathione to Oxidized Tyrosine Residues in Peptides and Proteins

Tyrosine residues are sensitive to oxidation and can be converted to hydroperoxides either by superoxide reacting with the Tyr radical or by singlet oxygen. These hydroperoxides rearrange to bicyclic derivatives that are readily reduced to more stable hydroxides. The aromatic character of tyrosine i...

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Autors principals: Nagy, Peter, Lechte, Thomas P., Das, Andrew B., Winterbourn, Christine C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406690/
https://ncbi.nlm.nih.gov/pubmed/22648418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371690
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