Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity

Tumor suppressor genes are frequently silenced in cancer cells by enzymes catalyzing epigenetic histone modifications. The peptidylarginine deiminase family member PAD4 (also called PADI4) is markedly overexpressed in a majority of human cancers, suggesting that PAD4 is a putative target for cancer...

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Bibliografiske detaljer
Main Authors: Wang, Yuji, Li, Pingxin, Wang, Shu, Hu, Jing, Chen, Xiangyun Amy, Wu, Jianhui, Fisher, Megan, Oshaben, Kira, Zhao, Na, Gu, Ying, Wang, Dong, Chen, Gong, Wang, Yanming
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406678/
https://ncbi.nlm.nih.gov/pubmed/22605338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.375725
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