A Lys49-PLA(2) myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling

Lys49-PLA(2) myotoxins, an important component of various viperid snake venoms, are a class of PLA(2)-homolog proteins deprived of catalytic activity. Similar to enzymatically active PLA(2) (Asp49) and to other classes of myotoxins, they cause severe myonecrosis. Moreover, these toxins are used as t...

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Autores principales: Tonello, F, Simonato, M, Aita, A, Pizzo, P, Fernández, J, Lomonte, B, Gutiérrez, J M, Montecucco, C
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406575/
https://ncbi.nlm.nih.gov/pubmed/22764102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.68
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