Tristetraprolin Inhibits Poly(A)-Tail Synthesis in Nuclear mRNA that Contains AU-Rich Elements by Interacting with Poly(A)-Binding Protein Nuclear 1

BACKGROUND: Tristetraprolin binds mRNA AU-rich elements and thereby facilitates the destabilization of mature mRNA in the cytosol. METHODOLOGY/PRINCIPAL FINDINGS: To understand how tristetraprolin mechanistically functions, we biopanned with a phage-display library for proteins that interact with tr...

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Bibliographic Details
Main Authors: Su, Yu-Lun, Wang, Shun-Chang, Chiang, Pei-Yu, Lin, Nien-Yi, Shen, Yu-Fang, Chang, Geen-Dong, Chang, Ching-Jin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406032/
https://ncbi.nlm.nih.gov/pubmed/22844456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041313
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