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Relative contributions of BRCA1 and BRCA2 mutations to “triple-negative” breast cancer in Ashkenazi Women

Approximately 10% of Ashkenazi Jewish (AJ) women with breast cancer (BC) carry a founder mutation in BRCA1 or BRCA2. There is an association between BRCA1 mutations and “triple-negative” breast cancer (TNBC) [estrogen receptor (ER) and progesterone receptor (PR) negative, HER2 negative]. We sought t...

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Autori principali: Comen, E., Davids, M., Kirchhoff, T., Hudis, C., Offit, K., Robson, M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405734/
https://ncbi.nlm.nih.gov/pubmed/21394499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-011-1433-2
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