Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2

Phosphatidylinositol 3-kinase (PI3-K) amplification and phosphatase and tensin homolog (PTEN) deletion-caused Akt activation contribute to the development of prostate cancer. Mammalian target of rapamycin complex 2 (mTORC2) is a kinase complex comprised of mTOR, Rictor, mSin1, mLST8/GβL and PRR5 and...

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Hlavní autoři: Liu, Kangdong, Park, Chanmi, Li, Shengqing, Lee, Ki Won, Liu, Haidan, He, Long, Soung, Nak Kyun, Ahn, Jong Seog, Bode, Ann M., Dong, Ziming, Kim, Bo Yeon, Dong, Zigang
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Carcinogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405653/
https://ncbi.nlm.nih.gov/pubmed/22532249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs156
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