Aloe-emodin mediates the inhibitory effect of LncRNA D63785 on the PI3K/Akt/mTOR pathway in nasopharyngeal carcinoma

BackgroundLong non-coding RNAs (lncRNAs) are dysregulated in nasopharyngeal carcinoma (NPC), yet their interplay with pharmacological agents like aloe-emodin (AE) remains unclear. This study explores AE’s anti-NPC mechanisms via lncRNA D63785 and the PI3K/Akt/mTOR pathway.MethodsNPC cells (CNE1, C66...

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Hlavní autoři:	Min He, Lei Xie, Jiayi Huang, Han Su, Jiahua Hu, Liuping Xie, Mengqin Li, Xin Zeng, Jianhong Tang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-07-01
Edice:	Frontiers in Pharmacology
Témata:	AE NPC LncRNA D63785 PI3K/Akt/mTOR signaling pathway proliferation and migration
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1573408/full
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