Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics

Ovarian cancer is the most lethal gynecological cancer. Here we show that innate immune agonist, dsRNA, directly induces ovarian cancer cell death and identify biomarkers associated with responsiveness to this targeted treatment. Nuclear staining and MTT assays following dsRNA stimulation revealed t...

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Detalhes bibliográficos
Main Authors: Van, Danielle N., Roberts, Charlotte F., Marion, James D., Lépine, Sandrine, Harikumar, Kuzhuvelil B., Schreiter, Jessica, Dumur, Catherine I., Fang, Xianjun, Spiegel, Sarah, Bell, Jessica K.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405273/
https://ncbi.nlm.nih.gov/pubmed/22532440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-202333
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