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Insulin resistance improves metabolic and contractile efficiency in stressed rat heart
Insulin resistance is a prominent feature in heart failure, while hyperglycemia impairs cardiac contraction. We propose that decreased insulin-mediated glucose uptake by the heart preserves cardiac function in response to metabolic and hemodynamic stress. To test this hypothesis, we fed rats a high-...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Federation of American Societies for Experimental Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3405268/ https://ncbi.nlm.nih.gov/pubmed/22611083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-208991 |
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