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Insulin resistance improves metabolic and contractile efficiency in stressed rat heart

Insulin resistance is a prominent feature in heart failure, while hyperglycemia impairs cardiac contraction. We propose that decreased insulin-mediated glucose uptake by the heart preserves cardiac function in response to metabolic and hemodynamic stress. To test this hypothesis, we fed rats a high-...

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Detalhes bibliográficos
Main Authors: Harmancey, Romain, Lam, Truong N., Lubrano, Genna M., Guthrie, Patrick H., Vela, Deborah, Taegtmeyer, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405268/
https://ncbi.nlm.nih.gov/pubmed/22611083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-208991
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