Sorafenib in advanced melanoma: a critical role for pharmacokinetics?

BACKGROUND: Inter-patient pharmacokinetic variability can lead to suboptimal drug exposure, and therefore might impact the efficacy of sorafenib. This study reports long-term pharmacokinetic monitoring of patients treated with sorafenib and a retrospective pharmacodynamic/pharmacokinetic analysis in...

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Detalhes bibliográficos
Main Authors: Pécuchet, N, Lebbe, C, Mir, O, Billemont, B, Blanchet, B, Franck, N, Viguier, M, Coriat, R, Tod, M, Avril, M-F, Goldwasser, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405224/
https://ncbi.nlm.nih.gov/pubmed/22767146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.287
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