Solution Structure of the LIM-Homeodomain Transcription Factor Complex Lhx3/Ldb1 and the Effects of a Pituitary Mutation on Key Lhx3 Interactions

Lhx3 is a LIM-homeodomain (LIM-HD) transcription factor that regulates neural cell subtype specification and pituitary development in vertebrates, and mutations in this protein cause combined pituitary hormone deficiency syndrome (CPHDS). The recently published structures of Lhx3 in complex with eac...

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Main Authors: Bhati, Mugdha, Lee, Christopher, Gadd, Morgan S., Jeffries, Cy M., Kwan, Ann, Whitten, Andrew E., Trewhella, Jill, Mackay, Joel P., Matthews, Jacqueline M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405102/
https://ncbi.nlm.nih.gov/pubmed/22848397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040719
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