Haploinsufficiency for Translation Elongation Factor eEF1A2 in Aged Mouse Muscle and Neurons Is Compatible with Normal Function

Translation elongation factor isoform eEF1A2 is expressed in muscle and neurons. Deletion of eEF1A2 in mice gives rise to the neurodegenerative phenotype “wasted” (wst). Mice homozygous for the wasted mutation die of muscle wasting and neurodegeneration at four weeks post-natal. Although the mutatio...

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Hlavní autoři: Griffiths, Lowri A., Doig, Jennifer, Churchhouse, Antonia M. D., Davies, Faith C. J., Squires, Charlotte E., Newbery, Helen J., Abbott, Catherine M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405021/
https://ncbi.nlm.nih.gov/pubmed/22848658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041917
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