Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

BACKGROUND: Ascorbic acid demonstrates a cytotoxic effect by generating hydrogen peroxide, a reactive oxygen species (ROS) involved in oxidative cell stress. A panel of eleven human cancer cell lines, glioblastoma and carcinoma, were exposed to serial dilutions of ascorbic acid (5-100 mmol/L). The p...

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Detalhes bibliográficos
Main Authors: Klingelhoeffer, Christoph, Kämmerer, Ulrike, Koospal, Monika, Mühling, Bettina, Schneider, Manuela, Kapp, Michaela, Kübler, Alexander, Germer, Christoph-Thomas, Otto, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404974/
https://ncbi.nlm.nih.gov/pubmed/22551313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6882-12-61
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