Genetic variants in the PI3K/PTEN/AKT/MTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention

PURPOSE: The development of second primary tumors (SPT) or recurrence alters prognosis for curatively-treated head and neck squamous cell carcinoma (HNSCC) patients. 13-cis-retnoic acid (13-cRA) has been tested as a chemoprevention agent in clinical trials with mixed results. Therefore, we investiga...

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Hlavní autoři: Hildebrandt, Michelle A.T., Lippman, Scott M., Etzel, Carol J., Kim, Edward, Lee, J. Jack, Khuri, Fadlo R., Spitz, Margaret R., Lotan, Reuben, Hong, Waun Ki, Wu, Xifeng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404728/
https://ncbi.nlm.nih.gov/pubmed/22577058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3271
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