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GDNF induces mechanical hyperalgesia in muscle by reducing I(BK) in IB4+ nociceptors

We have assessed the mechanism underlying glial cell-derived neurotrophic factor (GDNF)-induced mechanical hyperalgesia in the gastrocnemius muscle, using patch clamp electrophysiology, in vivo electrophysiology and behavioral studies. Cultured isolectin B4-positive (IB4+) dorsal root ganglion (DRG)...

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Autors principals: Hendrich, Jan, Alvarez, Pedro, Chen, Xiaojie, Levine, Jon D
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404506/
https://ncbi.nlm.nih.gov/pubmed/22704965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.06.011
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