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GDNF hyperalgesia is mediated by PLCγ, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican
The function of the isolectin B4 (IB4(+))-binding and GDNF-dependent Ret (Ret(+))-expressing non-peptidergic subpopulation of nociceptors remain poorly understood. We demonstrate that acute administration of GDNF sensitizes nociceptors and produces mechanical hyperalgesia in the rat. Intrathecal IB4...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660608/ https://ncbi.nlm.nih.gov/pubmed/18616564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2008.06308.x |
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