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E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

The p53 tumor suppressor protein is a transcription factor that exerts its effects on the cell cycle via regulation of gene expression. Although the mechanism of p53-dependent transcriptional activation has been well-studied, the molecular basis for p53-mediated repression has been elusive. The E2F...

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Detalhes bibliográficos
Main Authors: Carvajal, Luis A., Hamard, Pierre-Jacques, Tonnessen, Crystal, Manfredi, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404382/
https://ncbi.nlm.nih.gov/pubmed/22802528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.184911.111
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