Automated Screening of Microtubule Growth Dynamics Identifies MARK2 as a Regulator of Leading Edge Microtubules Downstream of Rac1 in Migrating Cells

Polarized microtubule (MT) growth in the leading edge is critical to directed cell migration, and is mediated by Rac1 GTPase. To find downstream targets of Rac1 that affect MT assembly dynamics, we performed an RNAi screen of 23 MT binding and regulatory factors and identified RNAi treatments that s...

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Bibliographic Details
Main Authors: Nishimura, Yukako, Applegate, Kathryn, Davidson, Michael W., Danuser, Gaudenz, Waterman, Clare M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404095/
https://ncbi.nlm.nih.gov/pubmed/22848487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041413
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