Selective Screening of Secretory Vesicle-Associated Proteins for Autoantigens in Type 1 Diabetes: VAMP2 and NPY are New Minor Autoantigens

The four major autoantigens (IA-2, I-2β, GAD65 and insulin) of type 1 diabetes are all associated with dense core or synaptic vesicles. This raised the possibility that other secretory vesicle-associated proteins might be targets of the autoimmune response in type 1 diabetes. To test this hypothesis...

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Main Authors: Hirai, Hiroki, Miura, Junnosuke, Hu, Yafang, Larsson, Helena, Larsson, Karin, Lernmark, Ake, Ivarsson, Sten-A., Wu, Tianxia, Kingman, Albert, Tzioufas, Athanasios G., Notkins, Abner L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403618/
https://ncbi.nlm.nih.gov/pubmed/18359275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2008.01.018
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