AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney

BACKGROUND AND PURPOSE: Renal ischaemia/reperfusion (RI/R) injury is a major cause of acute kidney injury (AKI) and an important determinant of long-term kidney dysfunction. AMP-kinase and histone deacetylase sirtuin 1 (SIRT1) regulate cellular metabolism and are activated during hypoxia. We investi...

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Bibliographic Details
Main Authors: Lempiäinen, J, Finckenberg, P, Levijoki, J, Mervaala, E
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2012
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402813/
https://ncbi.nlm.nih.gov/pubmed/22324445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01895.x
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