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Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function

Dysfunction of the heterogeneous ribonucleoprotein TAR DNA binding protein 43 (TDP-43) is associated with neurodegeneration in diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we examine the effects of a series of 4-aminoquinolines with affinity...

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Autors principals: Cassel, Joel A., McDonnell, Mark E., Velvadapu, Venkata, Andrianov, Vyacheslav, Reitz, Allen B.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402613/
https://ncbi.nlm.nih.gov/pubmed/22659571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2012.05.020
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