Doxycycline Regulated Induction of AKT in Murine Prostate Drives Proliferation Independently of p27 Cyclin Dependent Kinase Inhibitor Downregulation

The PI3 kinase/AKT pathway has been shown to increase degradation of the p27 cyclin dependent kinase inhibitor through phosphorylation of consensus AKT sites on p27 and SKP2, and AKT driven proliferation may be checked by feedback mechanisms that increase p27 expression and induce senescence. Howeve...

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Main Authors: Wang, Hongyun, Xu, Youyuan, Fang, Zi, Chen, Sen, Balk, Steven P., Yuan, Xin
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402521/
https://ncbi.nlm.nih.gov/pubmed/22844460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041330
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