Doxycycline Regulated Induction of AKT in Murine Prostate Drives Proliferation Independently of p27 Cyclin Dependent Kinase Inhibitor Downregulation

The PI3 kinase/AKT pathway has been shown to increase degradation of the p27 cyclin dependent kinase inhibitor through phosphorylation of consensus AKT sites on p27 and SKP2, and AKT driven proliferation may be checked by feedback mechanisms that increase p27 expression and induce senescence. Howeve...

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Detalhes bibliográficos
Main Authors: Wang, Hongyun, Xu, Youyuan, Fang, Zi, Chen, Sen, Balk, Steven P., Yuan, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402521/
https://ncbi.nlm.nih.gov/pubmed/22844460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041330
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