A Neurotoxic Phospholipase A(2) Impairs Yeast Amphiphysin Activity and Reduces Endocytosis

BACKGROUND: Presynaptically neurotoxic phospholipases A(2) inhibit synaptic vesicle recycling through endocytosis. PRINCIPAL FINDINGS: Here we provide insight into the action of a presynaptically neurotoxic phospholipase A(2) ammodytoxin A (AtxA) on clathrin-dependent endocytosis in budding yeast. A...

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Autors principals: Mattiazzi, Mojca, Sun, Yidi, Wolinski, Heimo, Bavdek, Andrej, Petan, Toni, Anderluh, Gregor, Kohlwein, Sepp D., Drubin, David G., Križaj, Igor, Petrovič, Uroš
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402474/
https://ncbi.nlm.nih.gov/pubmed/22844417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040931
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