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Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y(13) receptor

We have synthesized a series of derivatives of the known P2 receptor antagonist PPADS (pyridoxal-5′-phosphate-6-azo-phenyl-2,4-disulfonate) and examined their ability to inhibit functional activity of the recombinant human P2Y(13) nucleotide receptor expressed in 1321N1 human astrocytoma cells co-ex...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kim, Yong-Chul, Lee, Jung-Sun, Sak, Katrin, Marteau, Frederic, Mamedova, Liaman, Boeynaems, Jean-Marie, Jacobson, Kenneth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401943/
https://ncbi.nlm.nih.gov/pubmed/15913566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2005.04.021
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