PHYSIOLOGICAL CONSEQUENCES OF TRANSIENT OUTWARD K(+) CURRENT ACTIVATION DURING HEART FAILURE IN THE CANINE LEFT VENTRICLE

BACKGROUND: Remodeling of ion channel expression is well established in heart failure (HF). We determined the extent to which I(to) is reduced in tachypacing-induced HF and assessed the ability of an I(to) activator (NS5806) to recover this current. METHOD AND RESULTS: Whole-cell patch clamp was use...

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Detalhes bibliográficos
Main Authors: Cordeiro, Jonathan M, Calloe, Kirstine, Moise, N. Sydney, Kornreich, Bruce, Giannandrea, Dana, Di Diego, José M, Olesen, Søren-Peter, Antzelevitch, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401930/
https://ncbi.nlm.nih.gov/pubmed/22434032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.03.001
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