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The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands
A series of pyridylpiperazines was synthesized and analyzed for sigma receptor binding affinity to determine the optimal pyridyl nitrogen position and chain length for the σ(1) and σ(2) receptor recognition. The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor σ(1) receptors, while previously...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401592/ https://ncbi.nlm.nih.gov/pubmed/20338757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.02.087 |
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