Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

The Kelch-like 1 protein (KLHL1) is a neuronal actin-binding protein that modulates calcium channel function. It increases the current density of Ca(v)3.2 (α (1H)) calcium channels via direct interaction with α (1H) and actin-F, resulting in biophysical changes in Ca(v)3.2 currents and an increase i...

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Main Authors: Aromolaran, Kelly A., Benzow, Kelly A., Cribbs, Leanne L., Koob, Michael D., Piedras-Rentería, Erika S.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401526/
https://ncbi.nlm.nih.gov/pubmed/22848812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/505346
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