Calcium/Calmodulin Stimulates the Autophosphorylation of Elongation Factor 2 Kinase on Thr-348 and Ser-500 to Regulate its Activity and Calcium Dependence

Eukaryotic elongation factor 2 kinase (eEF-2K) is an atypical protein kinase regulated by Ca(2+) and calmodulin (CaM). Its only known substrate is eukaryotic elongation factor 2 (eEF-2), whose phosphorylation by eEF-2K impedes global protein synthesis. To date, the mechanism of eEF-2K autophosphoryl...

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Autori principali: Tavares, Clint D. J., O’Brien, John P., Abramczyk, Olga, Devkota, Ashwini K., Shores, Kevin S., Ferguson, Scarlett B., Kaoud, Tamer S., Warthaka, Mangalika, Marshall, Kyle D., Keller, Karin M., Zhang, Yan, Brodbelt, Jennifer S., Ozpolat, Bulent, Dalby, Kevin N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401519/
https://ncbi.nlm.nih.gov/pubmed/22329831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201788e
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