Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase

X-ray crystallography provides excellent structural data on protein–DNA interfaces, but crystallographic complexes typically contain only small fragments of large DNA molecules. We present a new approach that can use longer DNA substrates and reveal new protein–DNA interactions even in extensively s...

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Detalhes bibliográficos
Main Authors: Roberts, Victoria A., Pique, Michael E., Hsu, Simon, Li, Sheng, Slupphaug, Geir, Rambo, Robert P., Jamison, Jonathan W., Liu, Tong, Lee, Jun H., Tainer, John A., Ten Eyck, Lynn F., Woods, Virgil L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401472/
https://ncbi.nlm.nih.gov/pubmed/22492624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks291
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