Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase

X-ray crystallography provides excellent structural data on protein–DNA interfaces, but crystallographic complexes typically contain only small fragments of large DNA molecules. We present a new approach that can use longer DNA substrates and reveal new protein–DNA interactions even in extensively s...

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Main Authors: Roberts, Victoria A., Pique, Michael E., Hsu, Simon, Li, Sheng, Slupphaug, Geir, Rambo, Robert P., Jamison, Jonathan W., Liu, Tong, Lee, Jun H., Tainer, John A., Ten Eyck, Lynn F., Woods, Virgil L.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401472/
https://ncbi.nlm.nih.gov/pubmed/22492624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks291
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