Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function

FOXP3 is a key transcription factor for regulatory T cell function. We report the crystal structure of the FOXP3 coiled coil domain, through which a loose or transient dimeric association is formed and modulated, accounting for the activity variations introduced by disease-causing mutations or postt...

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Detalhes bibliográficos
Main Authors: Song, Xiaomin, Li, Bin, Xiao, Yan, Chen, Chunxia, Wang, Qiang, Liu, Yujie, Berezov, Alan, Xu, Chen, Gao, Yayi, Wu, Shiaw-Lin, Zhang, Hongtao, Karger, Barry L., Hancock, Wayne W., Wells, Andrew D., Zhou, Zhaocai, Greene, Mark I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401381/
https://ncbi.nlm.nih.gov/pubmed/22813742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.04.012
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