Self-Renewal of the Long-Term Reconstituting Subset of Hematopoietic Stem Cells is Regulated by Ikaros

Hematopoietic stem cells (HSCs) are rare, ancestral cells that underlie the development, homeostasis, aging, and regeneration of the blood. Here we show the chromatin-associated protein Ikaros is a crucial self-renewal regulator of the long-term (LT) reconstituting subset of HSCs. Ikaros, and associ...

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Hlavní autoři: Papathanasiou, Peter, Attema, Joanne L., Karsunky, Holger, Hosen, Naoki, Sontani, Yovina, Hoyne, Gerard F., Tunningley, Robert, Smale, Stephen T., Weissman, Irving L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401049/
https://ncbi.nlm.nih.gov/pubmed/19816952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.232
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