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Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening

Human pregnane X receptor (hPXR) plays a key role in regulating metabolism and clearance of endogenous and exogenous substances. Identification of novel hPXR activators among commercial drugs may aid in avoiding drug-drug interactions during coadministration. We applied ligand-based computational ap...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Pan, Yongmei, Li, Linhao, Kim, Gregory, Ekins, Sean, Wang, Hongbing, Swaan, Peter W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The American Society for Pharmacology and Experimental Therapeutics 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401010/
https://ncbi.nlm.nih.gov/pubmed/21068194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.035808
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