A Cytotoxic Type III Secretion Effector of Vibrio parahaemolyticus Targets Vacuolar H(+)-ATPase Subunit c and Ruptures Host Cell Lysosomes

Vibrio parahaemolyticus is one of the human pathogenic vibrios. During the infection of mammalian cells, this pathogen exhibits cytotoxicity that is dependent on its type III secretion system (T3SS1). VepA, an effector protein secreted via the T3SS1, plays a major role in the T3SS1-dependent cytotox...

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Bibliographic Details
Main Authors: Matsuda, Shigeaki, Okada, Natsumi, Kodama, Toshio, Honda, Takeshi, Iida, Tetsuya
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400558/
https://ncbi.nlm.nih.gov/pubmed/22829766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002803
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