Exploration of Synthetic Approaches and Pharmacological Evaluation of PNU-69176E and Its Stereoisomer as 5-HT(2C) Receptor Allosteric Modulators

[Image: see text] Allosteric modulators of the serotonin (5-HT) 5-HT(2C) receptor (5-HT(2C)R) present a unique drug design strategy to augment the response to endogenous 5-HT in a site- and event-specific manner with great potential as novel central nervous system probes and therapeutics. To date, P...

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Bibliographic Details
Main Authors: Ding, Chunyong, Bremer, Nicole M., Smith, Thressa D., Seitz, Patricia K., Anastasio, Noelle C., Cunningham, Kathryn A., Zhou, Jia
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400380/
https://ncbi.nlm.nih.gov/pubmed/22860223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300020x
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