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Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion
Stromal-derived growth factors are required for normal epithelial growth but are also implicated in tumour progression. We have observed inactivation of the retinoblastoma protein (Rb), through phosphorylation, in cancer-associated fibroblasts in oro-pharyngeal cancer specimens. Rb is well known for...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3400012/ https://ncbi.nlm.nih.gov/pubmed/22643222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.153 |
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