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Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation

Although the retinoblastoma protein (Rb) functions as a checkpoint in the cell cycle, it also regulates differentiation. It has recently been shown that Rb is acetylated during differentiation; however, the role of this modification has not been identified. Depletion of Rb levels with short hairpin...

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Detalhes bibliográficos
Main Authors: Pickard, Adam, Wong, Ping-Pui, McCance, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964107/
https://ncbi.nlm.nih.gov/pubmed/20940255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.068924
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