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Development of Elvitegravir Resistance and Linkage of Integrase Inhibitor Mutations with Protease and Reverse Transcriptase Resistance Mutations

Failure of antiretroviral regimens containing elvitegravir (EVG) and raltegravir (RAL) can result in the appearance of integrase inhibitor (INI) drug-resistance mutations (DRMs). While several INI DRMs have been identified, the evolution of EVG DRMs and the linkage of these DRMs with protease inhibi...

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Autors principals: Winters, Mark A., Lloyd, Robert M., Shafer, Robert W., Kozal, Michael J., Miller, Michael D., Holodniy, Mark
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399858/
https://ncbi.nlm.nih.gov/pubmed/22815755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040514
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