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Development of Elvitegravir Resistance and Linkage of Integrase Inhibitor Mutations with Protease and Reverse Transcriptase Resistance Mutations

Failure of antiretroviral regimens containing elvitegravir (EVG) and raltegravir (RAL) can result in the appearance of integrase inhibitor (INI) drug-resistance mutations (DRMs). While several INI DRMs have been identified, the evolution of EVG DRMs and the linkage of these DRMs with protease inhibi...

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Detalhes bibliográficos
Main Authors: Winters, Mark A., Lloyd, Robert M., Shafer, Robert W., Kozal, Michael J., Miller, Michael D., Holodniy, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399858/
https://ncbi.nlm.nih.gov/pubmed/22815755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040514
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