EGFR-PI3K-AKT-mTOR Signaling in Head and Neck Squamous Cell Carcinomas - Attractive Targets for Molecular-Oriented Therapy

IMPORTANCE OF THE FIELD: Recent advances in understanding the oncogenesis of head and neck squamous cell carcinomas (HNSCC) have revealed multiple dysregulated signaling pathways. One frequently altered axis is the EGFR/PI3K/Akt/mTOR pathway. This pathway plays a central role in numerous cellular pr...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Freudlsperger, Christian, Burnett, Jeffrey R., Friedman, Jay A., Kannabiran, Vishnu R., Chen, Zhong, Van Waes, Carter
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399735/
https://ncbi.nlm.nih.gov/pubmed/21110697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2011.541440
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