Lipopolysaccharide Up-regulates Alpha7 Acetylcholine Receptors: Stimulation with GTS-21 Mitigates Growth Arrest of Macrophages and Improves Survival in Burned Mice

Nicotinic stimulation of the alpha7 acetylcholine receptors (α7AChRs) mitigates the lipopolysaccharide (LPS)-induced TNF-α and other cytokines release in macrophages. This effect is blocked by α7AChR antagonist, α-bungarotoxin (BTX). We tested and confirmed the hypotheses that LPS up-regulates α7ACh...

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Main Authors: Khan, Mohammed Abdul Sattar, Farkhondeh, Mina, Crombie, Jennifer, Jacobson, Leslie, Kaneki, Masao, Jeevendra Martyn, J. A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399057/
https://ncbi.nlm.nih.gov/pubmed/22683726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e31825d628c
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