Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation

BACKGROUND: Induction of osteoblast differentiation by paracrine Sonic hedgehog (Shh) signaling may be a mechanism through which Shh-expressing prostate cancer cells initiate changes in the bone microenvironment and promote metastases. A hallmark of osteoblast differentiation is the formation of mat...

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Bibliografske podrobnosti
Main Authors: Zunich, Samantha M, Valdovinos, Maria, Douglas, Taneka, Walterhouse, David, Iannaccone, Philip, Lamm, Marilyn LG
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398858/
https://ncbi.nlm.nih.gov/pubmed/22559324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-30
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