APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair

APOBEC3 proteins catalyze deamination of cytidines in single-stranded DNA (ssDNA), providing innate protection against retroviral replication by inducing deleterious dC > dU hypermutation of replication intermediates. APOBEC3G expression is induced in mitogen-activated lymphocytes; however, no ph...

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Autors principals: Nowarski, Roni, Wilner, Ofer I., Cheshin, Ori, Shahar, Or D., Kenig, Edan, Baraz, Leah, Britan-Rosich, Elena, Nagler, Arnon, Harris, Reuben S., Goldberg, Michal, Willner, Itamar, Kotler, Moshe
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398754/
https://ncbi.nlm.nih.gov/pubmed/22645179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-402123
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